OCRP Research Highlights (FY97–Present)

OCRP Research Highlights (FY97–Present)

Notable Research Advances

• Showed that vitamin A analogs in combination with progestins stimulate selective apoptosis of ovarian cancer cell lines in vitro
• Generated a chicken model that can be used to study ovarian cancer
• Found that ovarian granulosa cells not only control the menstrual cycle but also control ovarian tumor development
• Discovered epithelial cell adhesion molecule as a possible biomarker for ovarian cancer
• Found that three HOX genes can be used as biomarkers to detect ovarian cancer
• Development of alpha-particle emitters as radiotherapeutics for advanced ovarian cancer
• Showed that squalamine is antiangiogenic and enhances the cytotoxic effect of cisplatin on ovarian cancer cells
• Found that the copper uptake protein CTR1 regulates cellular uptake of platinum drugs, which is important for overcoming drug resistance
• Discovered that poly-l-glutamate conjugated paclitaxel and hyaluronic acid conjugated paclitaxel can be used to overcome paclitaxel resistance